The mission of the Preuss School is to improve educational practices and provide an intensive college preparatory school for low-income student populations, which are historically underrepresented on the campuses of the University of California. The mission will thereby further the outreach efforts of the University of California and its commitment to the San Diego community and to educational intervention. Additionally, the school will support the district's goal of reducing the achievement gap among underrepresented students. The Preuss School's goals also support the district's mission statement by emphasizing the following:
The Preuss School provides an environment where students are continually encouraged and empowered to develop a greater sense of confidence and self-worth through self-sufficiency and a sense of pride in their academic accomplishments. The school fosters a culture of high academic performance in an environment that encourages risk-taking, the art of questioning and logical and critical thinking. Graduates will be stimulated to enjoy lifelong intellectual curiosity and dedication to continued learning. The school encourages the involvement of community, family and other institutions to share responsibility for encouraging young people to develop both scholars and citizens.